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Cedric Folens Selected Research

Pdgfra-Associated Chronic Eosinophilic Leukemia

8/2006Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant.
5/2006Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.

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Cedric Folens Research Topics

Disease

3Neoplasms (Cancer)
07/2008 - 04/2006
2Pdgfra-Associated Chronic Eosinophilic Leukemia
08/2006 - 05/2006
1Genetic Translocation (Chromosomal Translocation)
07/2008
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
04/2008
1Renal Cell Carcinoma (Grawitz Tumor)
08/2006
1Hematologic Neoplasms (Hematological Malignancy)
05/2006
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
04/2006

Drug/Important Bio-Agent (IBA)

3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2008 - 05/2006
3Imatinib Mesylate (Gleevec)FDA Link
04/2008 - 04/2006
2Phosphotransferases (Kinase)IBA
07/2008 - 04/2006
1Nuclear Pore Complex Proteins (Nucleoporins)IBA
07/2008
1Gamma Secretase Inhibitors and ModulatorsIBA
04/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
04/2008
1GlucocorticoidsIBA
04/2008
1Vincristine (Oncovin)FDA LinkGeneric
04/2008
1Therapeutic UsesIBA
04/2008
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
04/2008
1Sorafenib (BAY 43-9006)FDA Link
08/2006
1Proteins (Proteins, Gene)FDA Link
05/2006
1Protein Isoforms (Isoforms)IBA
04/2006
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
04/2006
1tyrosine receptor (receptor, tyrosine)IBA
04/2006
1Tyrosine Kinase InhibitorsIBA
04/2006
1Sunitinib (Sutent)FDA Link
04/2006

Therapy/Procedure

1Drug Therapy (Chemotherapy)
04/2008